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Despite gains made to decrease HIV viral load and recent advances in preventative options, reservoirs of infection remain. In Africa, rapidly expanding populations of vulnerable youth and young adults combined with threats of decreased donor funding creates further risks and urgency. The potential impact of emerging novel prevention products to significantly decrease acquisition of HIV infection is threatened by systems unable to support delivery and uptake, nor sustain effective use, of these products. These weak prevention delivery systems present a grave risk to the ability to address persistent pockets of infection and control HIV epidemics over the long-term.
The Blantyre Prevention Strategy (BPS) was co-developed with Malawi's government and a consortium of partners to support development of the optimal system for the sustained prevention of HIV infection that is fully embedded in local structures. The Ministry of Health chose District of Blantyre as the initial geography because it has the highest HIV incidence rate in country. Over five years (May 2020-April 2025), BPS will support strengthening and institutionalizing an innovative and data-driven HIV prevention delivery system at the district level that is equipped to detect and target risk, generate demand, effectively deliver prevention products and interventions, enable effective and sustained use of prevention products by the end user, and monitor performance and impact. Improved functioning of the HIV prevention cascade will result in an accelerated decline in HIV infections and long-term epidemic control.
Local insights and pathways for community-driven approaches are essential for developing an optimized system. BPS includes development of a data pipeline, is designed to provide a continuous process for generating local solutions to unique community challenges, networks and leverages private sectors, and applies human centered design and quality improvement to HIV prevention.

SA06.01 Introduction to the Blantyre Prevention Strategy
Sara ALLINDER, Georgetown University Center for Innovation in Global Health, United States
SA06.02 The Blantyre Prevention Strategy: Utilizing the prevention cascade as an organizing principle for a cohesive prevention program
Yohane KAMGWIRA, National AIDS Commission, Malawi
SA06.03 Application of the prevention cascade on subpopulations: Key populations and AGYW
Chimwemwe MABLEKISI, National AIDS Commission, Malawi
SA06.04 District-level HIV estimates for a more effective HIV response
Jeff EATON, Imperial College London, United Kingdom
SA06.05 The Role of IDSR and the Community Health Workforce in the HIV Prevention Response
Gift KAWALAZIRA, Blantyre District Health Office, Malawi
SA06.06 Optimizing data use in and outside of the facility: Catalyzing a multi-sectoral data pipeline fit for purpose for HIV prevention
Tyler SMITH, Cooper/Smith, United States
SA06.07 Generating Sustained Demand for HIV Prevention
Kudakwashe MUROMBEDZI, Population Services International, Malawi
SA06.08 Is QI the missing link to scaling-up prevention services?
Bruce AGINS, UCSF-Healthqual, United States
SA06.09 Hopes and Expectations for Novel HIV Prevention Technologies
Maureen LUBA, AVAC, Malawi
SA06.10 Closing remarks: Replicating a systems approach to HIV prevention
Chimwemwe MABLEKISI, National AIDS Commission, Malawi