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The primary results of the HPTN 071 (PopART) trial were published in July 2019. They showed that the PopART universal testing and treatment (UTT) intervention achieved the UNAIDS 90-90-90 targets within three years, and reduced HIV incidence at population level by about 20%. An unexpected finding was that stronger evidence of an effect on HIV incidence was found in Arm B (where ART was initially delivered according to national guidelines) than in Arm A (where immediate ART was offered throughout the trial). In this symposium, we present a number of additional analyses that have been carried out to gain a clearer understanding of the trial results. We hope that this symposium will help to build a clearer understanding of the results of the trial and their implications.

SA19.01 Introduction: Overview of trial and results
A. SMITH, IAS, Afghanistan
Helen AYLES, Zambart/LSHTM, United Kingdom
SA19.02 Did the PopART intervention lead to changes in sexual behavior? Were there differences in behavior between study arms?
Ethan WILSON, SCHARP, United States
SA19.03 Model projections: Did the mathematical model fit the data from the trial? What was the projected impact of the intervention if sustained over time and implemented more widely?
William PROBERT, University of Oxford, United Kingdom
SA19.04 How did ART adherence and viral suppression in those on ART compare between study arms and over time? Could poor adherence explain the lower impact in Arm A?
David MACLEOD, LSHTM, United Kingdom
SA19.05 What were the community-level correlates of HIV incidence in the trial? Could differences in community viral burden explain the differences in incidence between study arms and between communities?
Timothy SKALLAND, SCHARP, United States
SA19.06 Summary and concluding remarks
Richard HAYES, LSHTM, United Kingdom